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1996-02-27
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Document 0386
DOCN M9630386
TI Cerebral tuberculoma--a comparative study in patients with and without
HIV infection.
DT 9603
AU Martinez-Vazquez C; Bordon J; Rodriguez-Gonzalez A; de la Fuente-Aguado
J; Sopena B; Gallego-Rivera A; Martinez-Cueto P; Infectious Disease
Unit, Hospital Xeral of Vigo Medical School of; Santiago de Compostela
University, Spain.
SO Infection. 1995 May-Jun;23(3):149-53. Unique Identifier : AIDSLINE
MED/96121812
AB The microbiological, clinical and radiological findings of cerebral
tuberculomas in four patients with and in five patients without HIV
infection were compared. The study was carried out during the last 14
years. The CT scans were analyzed in a blinded fashion. Cerebral
tuberculoma in HIV-negative patients was clinically characterized by
seizures, while in HIV-positive patients this finding was absent. All
four HIV-infected patients had headache and fever and their CSF showed
lymphocytic meningitis. Two HIV-negative and three HIV-positive patients
had concurrent extracerebral tuberculosis. In HIV-infected patients, the
cerebral tuberculoma was a secondary finding of disseminated
tuberculosis. In our small patient samples, the cerebral tuberculoma
presented as spontaneous hypodense cerebral lesions in all the
HIV-positive patients but as a hyperdense cerebral lesion in the
HIV-negative patients. Two patients of each group had ring enhancement
lesions. Cerebral tuberculoma was diagnosed in about 4 weeks for
HIV-positive patients, but took some 16 weeks for HIV-negative patients,
the latter being first suspected of having a cerebral tumor or bacterial
abscess. Diagnostic craniotomy was thus necessary for the HIV-negative
patients. One patient of each group died as a consequence of cerebral
tuberculoma, all the remaining patients improved with treatment.
DE Adult Antitubercular Agents/THERAPEUTIC USE
Brain/PATHOLOGY/RADIOGRAPHY Case-Control Studies Cerebrospinal
Fluid/MICROBIOLOGY Comparative Study Female Fever/ETIOLOGY
Headache/ETIOLOGY Human HIV Infections/*COMPLICATIONS *HIV
Seronegativity Male Meningitis, Bacterial/ETIOLOGY Middle Age
Mycobacterium tuberculosis/ISOLATION & PURIF Seizures/ETIOLOGY
Tomography, X-Ray Computed Tuberculoma, Intracranial/DRUG
THERAPY/*ETIOLOGY/RADIOGRAPHY Tuberculosis, Pulmonary/COMPLICATIONS
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).